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Dihydroartemisinin (DHA) induces oxidative stress in cancer cells by increasing intracellular reactive oxygen species (ROS)

without considering these dynamics, interventions may miss the larger picture

Excessive ROS serve not only as a direct agent causing damage to biological macromolecules but also as a potent second messenger that activates key pro-inflammatory signaling pathways, such as NF-B and MAPK, through the oxidative modification of essential signaling proteins (62)

Chondrocyte models are derived from primary chondrocytes of animals such as rabbits and mice or the human-derived C28/12 chondrocyte cell line